17 dec. 2008 PARTICULARITATILE OVARULUI POLICHISTIC IN CICLURILE DE FERTILIZARE IN VITRO
Romeo Micu, Claudia Lazăr, Călin Perţa, Hudacsko Haznalka Aurora
Clinica Obstetrica-Ginecologie 1, Spitalul Clinic Judetean Cluj
Rezumat
Obiective. Evidentierea unor particularitati ale ovarului polichistic (SOPC), comparat cu ovarul normal in cadrul ciclurilor de fertilizare in vitro.
Material şi metodă Este un studiu retrospectiv efectuat in Clinica de Obstetrica si Ginecologie I din Cluj-Napoca care a inclus 140 paciente cu sterilitate de cauza tubara (126 paciente) si cu SOPC (14 paciente) internate in clinica intre 2000-2007.
Rezultate. In cazurile cu SOPC comparativ cu lotul cu sterilitate prin obstructie tubara, este necesar un numar mai mare de unitati rFSH/uHMG pentru stimularea ovariana, numarul de ovocite recoltate este mai mare, in timp ce numarul de embrioni obtinuti, respectiv transferati, precum si numarul de sarcini obtinute, nu difera semnificativ intre cele doua loturi. Sindromul de hiperstimulare pare sa fie mai frecvent in lotul cu SOPC.
Concluzii. Ovarul polichistic are o rezistenţă crescută la medicaţia specifică, dar odată obţinută stimularea, răspunsul este accentuat, se obţin mai multe ovocite, dar de calitate mai slabă, prezentând, totodată, un risc mai crescut de sindrom de hiperstimulare.
Abstract – THE FEATURES OF POLYCYSTIC OVARY IN IVF CYCLES
Objective. The highlight of some features of Polycystic Ovary Syndrome (PCOS) versus normal ovary during the In Vitro Fertilization (IVF) cycles.
Study design. A retrospective study conducted in the Gynecology and Obstetrics Clinic I from Cluj-Napoca included 140 patients admitted between 2000-2007 with infertility due to tubal dysfunction (126 patients) and PCOS (14 patients).
Results. Comparing with the infertility cases due to fallopian tube obstruction, the cases with PCOS required more rFSH/uHMG units for ovarian hyperstimulation and the number of the retrieved oocyte is bigger. However, the number of the cultured embryo, respectively transferred embryo, as well as the number of the resulted pregnancies are not significantly different between the two batches. The Ovarian Hyperstimulation Syndrome seems to occur more frequently in the PCOS batch.
Conclusion. The polycystic ovary presents an incresead resistance to the specific medication, but once the stimulation obtained, the response is enhanced, the oocyte retrieval is augmented, while the oocytes are of lesser quality and the risk of Ovarian Hyperstimulation Syndrome is higher.
Key words: FIV, policystic ovary